منابع مشابه
Microbiological studies with thioctic acid analogues. I. Inhibitory effects of 6-ethyl-8-mercaptooctanoic acid and related thioctic acid analogues for growth of microorganisms.
Present knowledge of the metabolic role of thioctic acid (lipoic acid) is derived almost exclusively from studies of bacterial enzyme systems, although it may well have similar functions in higher plants and animals. A number of microorganisms are known which have an absolute growth requirement for thioctic acid but higher animals do not seem to require preformed thioctic acid for growth. If ef...
متن کاملRemoval of thioctic acid from enzymes.
The r81e of thioctic acid in t’he oxidative decarboxylation of or-keto acids is now well established (1, 2). This was accomplished largely by studies with microbial cells grown essentially free of the cofactor. In some instances (2) it has been possible t,o separate the coenzyme from microbial enzymes involved in t,hioctic acid metabolism by extensive purification procedures. Although tjhe dire...
متن کاملMetabolism of thioctic acid in algae.
Thioctic acid labeled with sulfur-35 has been p repa red and i t s metabol ism b y algae has been studied. It i s converted by the algae into a number of f o r m s , all of which upon hydrolysis yield either the disulfide o r i t s sulfoxide. One of these constituted the major portion of the labeled ma te r i a l in the chlorop1;~sts . Aerobic metabolism for some minutes i s required to produce...
متن کاملThioctic Acid: Physics, Chemistry, and Biology
This paper consti tutes a review of the exper imenta l events that l ed o u r l abo ra to ry to focus i t s attention on thioctic acid , a d i scuss ion of some of the pu re ly chemica l and physical p roper t ies of thioctic acid that this awakened i n t e r e s t p rompted us to invest igate , and a br ief descr ip t ion of some of o u r recen t biological investigations with thioctic acid.
متن کاملThioctic Acid in the Treatment of Poisoning. with Alpha-Amanitin
Between August 8, 1974, and November 1, 1978, calls reporting 100 cases of mushroom poisoning were received by the National Institutes of Health. Thioctic acid was sent (under IND # 9957) for the treatment of seventy-five of these patients thought to have ingested mushrooms containing alpha-amanitin. Sixty-seven patients recovered, and eight died. The lapse of time between ingestion of mushroom...
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ژورنال
عنوان ژورنال: Acta Chemica Scandinavica
سال: 1957
ISSN: 0904-213X
DOI: 10.3891/acta.chem.scand.11-1607